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  • 產(chǎn)品名稱： Recombinant Human ELOB/ELOC/VHL Complex Protein
  • 產(chǎn)品貨號(hào)： CS05649
  • 貨期： 現(xiàn)貨
  • 價(jià)格與訂購(gòu)： 590
  • 數(shù)量：
    庫(kù)存： 10
  • 規(guī)格： 10ug 50ug
  • 產(chǎn)品信息
  • 如何訂購(gòu)
    別名
    Elongin B & Elongin C & VHL; ELOB & ELOC & VHL Complex; Elongin B & Elongin C & VHL Complex
    種屬
    Human
    來(lái)源
    Baculovirus-Insect Cells
    分子量
    14 kDa (ElOB) and 13.3 kDa (ElOC) and 25.9 kDa (VHL)
    外觀
    Liquid
    形態(tài)
    40mM Tris, 200mM NaCl, 2.2mM KCl, 20% glycerol, 3mM DTT, pH8.0
    序列
    ELOB flag tag, Human, Asp2-Gln118, N-flag DYKDDDDKDVFLMIRRHKTTIFTDAKESSTVFELKRIVEGILKRPPDEQRLYKDDQLLDDGKTLGECGFTSQTARPQAPATVGLAFRADDTFEALCIEPFSSPPELPDVMKPQDSGSSANEQAVQ ELOC flag tag, Human, Asp2-Cys112, N-flag DYKDDDDKDGEEKTYGGCEGPDAMYVKLISSDGHEFIVKREHALTSGTIKAMLSGPGQFAENETNEVNFREIPSHVLSKVCMYFTYKVRYTNSSTEIPEFPIAPEIALELLMAANFLDC VHL His tag, Human, Pro2-Asp213, N-His HHHHHHHHHHGGGSGGGSPRRAENWDEAEVGAEEAGVEEYGPEEDGGEESGAEESGPEESGPEELGAEEEMEAGRPRPVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHSYRGH
    LWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKERCLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLTQERIAHQRMGD
    標(biāo)簽
    No Tag
    Accession
    Q15370
    純度
    ＞95% by SDS-PAGE
    內(nèi)毒素水平
    <0.1EU/ug
    溶解方法
    N.A
    儲(chǔ)存/保存方法
    Within 1 week, 2 to 8 °C under sterile conditions after reconstitution. 12 months from date of receipt, -20 to -80 °C as supplied. Avoid repeated freeze-thaw cycles.
    背景說(shuō)明
    ELOB (elongin B) is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. ELOB and ELOC(elongin C) form a heterodimer that serves as the regulatory subunit for the Elongin complex-a general transcription elongation factor that increases RNA Polymerase II transcription through template-encoded arresting sites. The ELOB/ELOC complex also binds to the "BC-box motif" found in many proteins in the VHL-box and SOCS-box protein families. The VHL(von Hippel-Lindau disease tumor suppressor) binds to ELOB and ELOC and thereby inhibits transcription elongation.
    參考文獻(xiàn)
    1.Cell Chem Biol. 2023 Jul 20;30(7):766-779.e11. Epub 2023 Jun 23.
    2.bioRxiv. 2023 May 24;2023.05.22.541439. PreprintOkumura F., et al. (2012) Front. Oncol.
    3.Mod Pathol. 2023 Apr 23;36(8):100194. Online ahead of print.
    Note
    For research use only.